Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles

The Hsp70 chaperone system is integrated into a myriad of biochemical processes that are critical for cellular proteostasis. Although detailed pictures of Hsp70 bound with peptides have emerged, correspondingly detailed structural information on complexes with folding-competent substrates remains la...

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Bibliographic Details

Published in:	eLife
Main Authors:	Rina Rosenzweig, Ashok Sekhar, Jayashree Nagesh, Lewis E Kay
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2017-07-01
Subjects:	Hsp70 conformational heterogeneity methyl-TROSY NMR molecular chaperones protein folding
Online Access:	https://elifesciences.org/articles/28030