Aggressive variants of prostate cancer: underlying mechanisms of neuroendocrine transdifferentiation

Abstract Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against androgen synthesis or AR activation is broadly used and continually improved. However, a subset of patients eventua...

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Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Lina Merkens, Verena Sailer, Davor Lessel, Ella Janzen, Sarah Greimeier, Jutta Kirfel, Sven Perner, Klaus Pantel, Stefan Werner, Gunhild von Amsberg
Format:	Article
Language:	English
Published:	BMC 2022-02-01
Subjects:	Aggressive variant prostate cancer Small cell prostate cancer Neuroendocrine prostate cancer Neuroendocrine transdifferentiation
Online Access:	https://doi.org/10.1186/s13046-022-02255-y