Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility

Based upon our demonstration that the smooth muscle cell–selective (SMC-selective) putative methyltransferase, Prdm6, interacts with myocardin-related transcription factor-A, we examined Prdm6’s role in SMCs in vivo using cell type–specific knockout mouse models. Although SMC-specific depletion of P...

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Bibliographic Details

Published in:	JCI Insight
Main Authors:	Meng Zou, Kevin D. Mangum, Justin C. Magin, Heidi H. Cao, Michael T. Yarboro, Elaine L. Shelton, Joan M. Taylor, Jeff Reese, Terrence S. Furey, Christopher P. Mack
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2023-03-01
Subjects:	Vascular biology
Online Access:	https://doi.org/10.1172/jci.insight.163454