Hijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated Neoplastic Phenotypes

The epithelial-mesenchymal transition (EMT) is a highly conserved program necessary for orchestrating distant cell migration during embryonic development. Multiple studies in cancer have demonstrated a critical role for EMT during the initial stages of tumorigenesis and later during tumor invasion....

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Kekoa eTaparra, Phuoc eTran, Natasha eZachara
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-04-01
Subjects:	Glycoproteins Glycosylation Metabolism senescence O-GlcNAc O-GlcNAcylation
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00085/full