The Ras/MAPK pathway is required for generation of iNKT cells.
iNKT cells derive from CD4(+)CD8(+) DP thymocytes, and are selected by thymocyte-thymocyte interactions through signals from their invariant Vα14-Jα18 TCR and from the costimulatory molecules SLAMF1 and SLAMF6. Genetic studies have demonstrated the contribution of different signaling pathways to thi...
| 出版年: | PLoS ONE |
|---|---|
| 主要な著者: | , , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Public Library of Science (PLoS)
2011-05-01
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| オンライン･アクセス: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0019890&type=printable |