Bispecific killer cell engagers employing species cross-reactive NKG2D binders redirect human and murine lymphocytes to ErbB2/HER2-positive malignancies

NKG2D is an activating receptor expressed by natural killer (NK) cells and other cytotoxic lymphocytes that plays a pivotal role in the elimination of neoplastic cells through recognition of different stress-induced cell surface ligands (NKG2DL). To employ this mechanism for cancer immunotherapy, we...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Jordi Pfeifer Serrahima, Katrin Schoenfeld, Ines Kühnel, Julia Harwardt, Arturo Macarrón Palacios, Maren Prüfer, Margareta Kolaric, Pranav Oberoi, Harald Kolmar, Winfried S. Wels
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-08-01
Subjects:	bispecific killer cell engager BiKE NKG2D ErbB2 HER2 natural killer cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1457887/full