Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging

Abstract DNA hydroxymethylation (5hmC), the most abundant oxidative derivative of DNA methylation, is typically enriched at enhancers and gene bodies of transcriptionally active and tissue-specific genes. Although aberrant genomic 5hmC has been implicated in age-related diseases, its functional role...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	James R. Occean, Na Yang, Yan Sun, Marshall S. Dawkins, Rachel Munk, Cedric Belair, Showkat Dar, Carlos Anerillas, Lin Wang, Changyou Shi, Christopher Dunn, Michel Bernier, Nathan L. Price, Julie S. Kim, Chang-Yi Cui, Jinshui Fan, Moitrayee Bhattacharyya, Supriyo De, Manolis Maragkakis, Rafael de Cabo, Simone Sidoli, Payel Sen
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-07-01
Online Access:	https://doi.org/10.1038/s41467-024-50725-y