LIN28B-mediated PI3K/AKT pathway activation promotes metastasis in colorectal cancer models

Colorectal cancer (CRC) remains a leading cause of cancer death because of metastatic spread. LIN28B is overexpressed in 30% of CRCs and promotes metastasis, yet its mechanisms remain unclear. In this study, we genetically modified CRC cell lines to overexpress LIN28B, resulting in enhanced PI3K/AKT...

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Bibliographic Details

Published in:	The Journal of Clinical Investigation
Main Authors:	Alice E. Shin, Kensuke Sugiura, Secunda W. Kariuki, David A. Cohen, Samuel P. Flashner, Andres J. Klein-Szanto, Noriyuki Nishiwaki, Dechokyab De, Neil Vasan, Joel T. Gabre, Christopher J. Lengner, Peter A. Sims, Anil K. Rustgi
Format:	Article
Language:	English
Published:	American Society for Clinical Investigation 2025-04-01
Subjects:	Gastroenterology Oncology
Online Access:	https://doi.org/10.1172/JCI186035