Dabigatran Suppresses PAR-1/SphK/S1P Activation of Astrocytes in Experimental Autoimmune Encephalomyelitis Model

Multiple sclerosis (MS) is an inflammatory autoimmune disease affecting the central nervous system (CNS) that currently does not have any effective treatment. Experimental autoimmune encephalomyelitis (EAE) is often employed as a model to mimic the clinical manifestations of MS, mainly CNS demyelina...

Full description

Bibliographic Details

Published in:	Frontiers in Molecular Neuroscience
Main Authors:	Rong Chen, Xing Cao, Wenxiu Luo, Haodi Yang, Xinya Luo, Juming Yu, Jiaming Luo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-06-01
Subjects:	multiple sclerosis experimental autoimmune encephalomyelitis dabigatran protease-activated receptors sphingosine-1-phosphate coagulation
Online Access:	https://www.frontiersin.org/article/10.3389/fnmol.2020.00114/full