Recent advances in polygenic scores: translation, equitability, methods and FAIR tools

Abstract Polygenic scores (PGS) can be used for risk stratification by quantifying individuals’ genetic predisposition to disease, and many potentially clinically useful applications have been proposed. Here, we review the latest potential benefits of PGS in the clinic and challenges to implementati...

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Bibliographic Details

Published in:	Genome Medicine
Main Authors:	Ruidong Xiang, Martin Kelemen, Yu Xu, Laura W. Harris, Helen Parkinson, Michael Inouye, Samuel A. Lambert
Format:	Article
Language:	English
Published:	BMC 2024-02-01
Subjects:	Polygenic score (PGS) Clinical utility FAIR (Findable Accessible Interoperable And Reusable)
Online Access:	https://doi.org/10.1186/s13073-024-01304-9