ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion

Ataxia-telangiectasia mutated (ATM) protein kinase regulates the DNA damage response (DDR) and is associated with cancer suppression. Here we report a cancer-promoting role for ATM. ATM depletion in metastatic cancer cells reduced cell migration and invasion. Transcription analyses identified a gene...

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發表在:	eLife
Main Authors:	Wei-Ta Chen, Nancy D Ebelt, Travis H Stracker, Blerta Xhemalce, Carla L Van Den Berg, Kyle M Miller
格式:	Article
語言:	英语
出版:	eLife Sciences Publications Ltd 2015-06-01
主題:	DNA damage ATM IL-8 cell migration ROS
在線閱讀:	https://elifesciences.org/articles/07270