Design, Synthesis and In Vitro Investigation of Novel Basic Celastrol Carboxamides as Bio-Inspired Leishmanicidal Agents Endowed with Inhibitory Activity against <i>Leishmania</i> Hsp90

The natural triterpene celastrol (<b>CE</b>) is here used as lead compound for the design and synthesis of a panel of eleven <b>CE</b> carboxamides that were tested in vitro for their growth inhibitory activity against <i>Leishmania infantum</i> and <i>L.<...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Ivan Bassanini, Silvia Parapini, Erica E. Ferrandi, Elena Gabriele, Nicoletta Basilico, Donatella Taramelli, Anna Sparatore
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Subjects:	celastrol natural compounds <i>Leishmania</i> Hsp90 Hsp90 inhibition leishmanicidal compounds protozoa
Online Access:	https://www.mdpi.com/2218-273X/11/1/56