Copper homeostasis and cuproptosis: implications for neurodegenerative diseases

Copper (Cu) is a vital trace element required for sustaining life and is involved in numerous critical metabolic processes within the body. Cuproptosis, a newly recognized type of Cu-dependent cell death, is mechanistically distinct from apoptosis, autophagy, pyroptosis, and ferroptosis. It is chara...

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Bibliographic Details

Published in:	Frontiers in Aging Neuroscience
Main Authors:	Feng Tao, Mengxuan Lin, Xiang Meng, Linghui Huang, Bifang Zhuo, Siyi Jiang, Shizhe Deng, Zhihong Meng, Jiangwei Shi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	copper cuproptosis copper homeostasis neurodegenerative diseases cell death
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2025.1688554/full