Thymocytes in Lyve1-CRE/S1pr1f/f mice accumulate in the thymus due to cell-intrinsic loss of sphingosine-1-phosphate receptor expression

T cell emigration from the thymus is essential for immunological homeostasis. While stromal cell-produced sphingosine-1-phosphate (S1P) has been shown to promote thymocyte egress via the S1P receptor, S1PR1, the significance of S1P/S1PR1 signaling in the thymic stromal cells that surround T cells re...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Akira Takeda, Mohammad Shahadat Hossain, Pia Rantakari, Szandor Simmons, Naoko Sasaki, Marko Salmi, Sirpa Jalkanen, Masayuki Miyasaka
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-11-01
Subjects:	Egress Sphingosine-1-phosphate Thymus S1PR1 LYVE1
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00489/full