Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice

Abstract: The hematopoietically expressed homeobox (Hhex) transcription factor is overexpressed in human myeloid leukemias. Conditional knockout models of murine acute myeloid leukemia indicate that Hhex maintains leukemia stem cell self-renewal by enabling Polycomb-mediated epigenetic repression of...

Full description

Bibliographic Details

Published in:	Blood Advances
Main Authors:	Jacob T. Jackson, Ashley P. Ng, Benjamin J. Shields, Sue Haupt, Ygal Haupt, Matthew P. McCormack
Format:	Article
Language:	English
Published:	Elsevier 2018-02-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2473952920310867