Analytical approach for identification and mechanistic insights into mRNA-lipid adduct formation

Messenger ribonucleic acid (mRNA), a promising tool in vaccine and therapeutic development, is reliant on intact mRNA delivery into target cells. Given its susceptibility to degradation, ensuring its stability is crucial, necessitating rigorous quality control throughout the product life cycle. This...

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Bibliographic Details

Published in:	Molecular Therapy: Nucleic Acids
Main Authors:	Sebastien Peronin, Camille Malburet, Chamsan Daher-Hassan, Christelle Picard, Thibaut Willemin, Federica Costamagna, Luc Even, Thierry Eynard, Fethi Bensaid, Stéphanie Fertier-Prizzon, Marc Francois-Heude
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Subjects:	Delivery Strategies mRNA-lipid adducts lipid nanoparticles drug delivery liquid chromatography mass spectrometry
Online Access:	http://www.sciencedirect.com/science/article/pii/S2162253125002380