Deep3DSIM: Super-resolution imaging of thick tissue using 3D structured illumination with adaptive optics

Three-dimensional structured illumination microscopy (3D-SIM) doubles the resolution of fluorescence imaging in all directions and enables optical sectioning with increased image contrast. However, 3D-SIM has not been widely applied to imaging deep in thick tissues due to its sensitivity to sample-i...

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Bibliographic Details

Published in:	eLife
Main Authors:	Jingyu Wang, Danail Stoychev, Mick A Phillips, David Miguel Susano Pinto, Richard M Parton, Nicholas James Hall, Joshua S Titlow, Ana Rita Faria, Matthew Wincott, Dalia Gala, Andreas Gerondopoulos, Niloufer Irani, Ian Dobbie, Lothar Schermelleh, Martin J Booth, Ilan Davis
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-10-01
Subjects:	3D-SIM super-resolution microscopy neuroscience adaptive optics aberration correction nervous system
Online Access:	https://elifesciences.org/articles/102144