Using network toxicology and molecular docking to identify core targets and pathways underlying tacrolimus-induced tremor in organ transplant recipients

Abstract Tacrolimus, the most commonly prescribed immunosuppressant following organ transplantation, is associated with various neurotoxic effects, notably tremor, which significantly impacts the quality of life of recipients. The precise mechanisms underlying tacrolimus-induced tremor remain unclea...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Chao Liu, Qian Chen, Fu Yan, Yulin Niu
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Subjects:	Network toxicology Molecular Docking Tacrolimus Tremor Organ transplantation
Online Access:	https://doi.org/10.1038/s41598-025-02381-5