ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis

The strongest genetic risk factor for sporadic Alzheimer’s disease (AD) is the presence of the ε4 allele of the apolipoprotein E (ApoE) gene, the major apolipoprotein involved in brain cholesterol homeostasis. Being astrocytes the main producers of cholesterol and ApoE in the brain, we investigated...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Erica Staurenghi, Valerio Leoni, Marco Lo Iacono, Barbara Sottero, Gabriella Testa, Serena Giannelli, Gabriella Leonarduzzi, Paola Gamba
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Subjects:	astrocytes alzheimer’s disease apolipoprotein E ApoE4 cholesterol metabolism lipids
Online Access:	https://www.mdpi.com/2076-3921/11/11/2168