Integrating neuroimaging biomarkers into the multicentre, high-dose erythropoietin for asphyxia and encephalopathy (HEAL) trial: rationale, protocol and harmonisation

Introduction MRI and MR spectroscopy (MRS) provide early biomarkers of brain injury and treatment response in neonates with hypoxic-ischaemic encephalopathy). Still, there are challenges to incorporating neuroimaging biomarkers into multisite randomised controlled trials. In this paper, we provide t...

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Published in:	BMJ Open
Main Authors:	Taeun Chang, Brenda Poindexter, Gregory M. Sokol, Ashok Panigrahy, Stefan Bluml, Patrick J Heagerty, Mark Smith, Jessica L Wisnowski, Amit M Mathur, Jeffrey Berman, Ping-Sun Keven Chen, James Dix, Trevor Flynn, Stanley Fricke, Seth D Friedman, Hayden W Head, Chang Y Ho, Beth Kline-Fath, Michael Oveson, Richard Patterson, Sumit Pruthi, Nancy Rollins, Yanerys M Ramos, John Rampton, Jerome Rusin, Dennis W Shaw, Jean Tkach, Shreyas Vasanawala, Arastoo Vossough, Matthew T Whitehead, Duan Xu, Kristen Yeom, Bryan Comstock, Sandra E Juul, Yvonne W Wu, Robert C McKinstry, Kaashif Ahmed, Mariana Beserga, Ellen Bendel-Stenzel, Lina Chalak, John Flibotte, Fernando Gonzalez, Andrea Lampland, Nathalie Maitre, Amit M. Mathur, Dennis Mayock, Ulrike Mietzsch, Rakesh Rao, David Riley, Krisa Van Meurs, Hendrik Weitkamp, Tai-Wei Wu, Toby Yanowitz
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2021-04-01
Online Access:	https://bmjopen.bmj.com/content/11/4/e043852.full