Type I/type III IFN and related factors regulate JEV infection and BBB endothelial integrity

Abstract Background Japanese encephalitis virus (JEV) remains a predominant cause of Japanese encephalitis (JE) globally. Its infection is usually accompanied by disrupted blood‒brain barrier (BBB) integrity and central nervous system (CNS) inflammation in a poorly understood pathogenesis. Productiv...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Ya-Ge Zhang, Hong-Xin Zhang, Hao-Wei Chen, Penghao Lv, Jie Su, Yan-Ru Chen, Zhen-Fang Fu, Min Cui
Format:	Article
Language:	English
Published:	BMC 2023-09-01
Subjects:	Japanese encephalitis virus Human brain microvascular endothelial cells RNA-Seq PRRs IFNs IFITs
Online Access:	https://doi.org/10.1186/s12974-023-02891-x