Physiologically Based Pharmacokinetic Modeling in Pregnant Women Suggests Minor Decrease in Maternal Exposure to Olanzapine

Pregnancy is accompanied by significant physiological changes that might affect the in vivo drug disposition. Olanzapine is prescribed to pregnant women with schizophrenia, while its pharmacokinetics during pregnancy remains unclear. This study aimed to develop a physiologically based pharmacokineti...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Liang Zheng, Hongyi Yang, André Dallmann, Xuehua Jiang, Ling Wang, Wei Hu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Subjects:	olanzapine PBPK pregnancy metabolic enzymes pharmacokinetics
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.793346/full