Single-cell transcriptomics in MI identify Slc25a4 as a new modulator of mitochondrial malfunction and apoptosis-associated cardiomyocyte subcluster

Abstract Myocardial infarction (MI) is the leading cause of premature death. The death of cardiomyocytes (CMs) and the dysfunction of the remaining viable CMs are the main pathological factors contributing to heart failure (HF) following MI. This study aims to determine the transcriptional profile o...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Ting Zhou, Jing Pan, Kai Xu, Chenghui Yan, Jing Yuan, Haixu Song, Yaling Han
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Subjects:
Single nuclei RNA sequencing
Mitochondrial malfunction
Apoptosis
Heart failure
Online Access:https://doi.org/10.1038/s41598-024-59975-8

Internet

https://doi.org/10.1038/s41598-024-59975-8

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