Synergistic inhibitory effects of Trifolium pratense L. extract and doxorubicin on 4T1 tumor-bearing mice are mediated via targeting the Wnt/β-catenin pathway and reversal of epithelial-mesenchymal transition

Objective: Triple-negative breast cancer (TNBC) presents significant therapeutic challenges. This study investigates the combination effects of Trifolium pratense L. (red clover) and doxorubicin (DOX) on the Wnt/β-catenin signaling pathway, epithelial-mesenchymal transition (EMT) and apoptosis in 4T...

Full description

Bibliographic Details

Published in:	Avicenna Journal of Phytomedicine
Main Authors:	Saeed khazayel, Mohammad Hossein Faraji, mohsen akbari bazm, Mozafar khazaei, Elham Niromand, Mohammad Rasool khazaei
Format:	Article
Language:	English
Published:	Mashhad University of Medical Sciences 2025-09-01
Subjects:	trifolium pratense l. doxorubicin epithelial mesenchymal transition wnt signaling pathway beta catenin
Online Access:	https://ajp.mums.ac.ir/article_25940_b84f009d5d61724cc229720ad4118562.pdf