A Hybrid UA–CG Force Field for Aggregation Simulation of Amyloidogenic Peptide via Liquid-like Intermediates

Elucidating amyloid formation inside biomolecular condensates requires models that resolve (i) local, chemistry specific contacts controlling β registry and (ii) mesoscale phase behavior and cluster coalescence on microsecond timescales—capabilities beyond single resolution models. We present a hybr...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Hang Zheng, Shu Li, Wei Han
Format:	Article
Language:	English
Published:	MDPI AG 2025-10-01
Subjects:	hybrid resolution simulation biomolecular condensates liquid–liquid phase separation amyloidogenesis reaction limited coalescence
Online Access:	https://www.mdpi.com/1420-3049/30/19/3946