Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans.

Preventing germline stem cell proliferation extends lifespan in nematodes and flies. So far, studies on germline-longevity signaling have focused on daf-16/FOXO and daf-12/VDR. Here, we report on NHR-80/HNF4, a nuclear receptor that specifically mediates longevity induced by depletion of the germ li...

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Bibliographic Details

Published in:	PLoS Biology
Main Authors:	Jérôme Goudeau, Stéphanie Bellemin, Esther Toselli-Mollereau, Mehrnaz Shamalnasab, Yiqun Chen, Hugo Aguilaniu
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-03-01
Online Access:	http://europepmc.org/articles/PMC3057950?pdf=render