Solid Organ Transplantation Is Associated with an Increased Rate of Mismatch Repair Deficiency and PIK3CA Mutations in Colorectal Cancer

Solid organ transplants are associated with a modestly increased risk of colorectal cancers (CRC). However, the molecular profile of these cancers has not been described. We hypothesized that transplant-related immunosuppression may promote development of more immunogenic tumors as suggested by a hi...

Full description

Bibliographic Details

Published in:	Current Oncology
Main Authors:	Eric S. Christenson, Valerie Lee, Hao Wang, Mark Yarchoan, Ana De Jesus-Acosta, Nilo Azad, Ahmet Gurakar, Ming-Tseh Lin, Dung T. Le, Daniel C. Brennan, Elizabeth M. Jaffee, Katherine Bever
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Subjects:	mismatch repair deficient colon cancer PIK3CA mutations calcineurin Inhibitors post-transplant malignancies high tumor mutation burden tumors immune surveillance
Online Access:	https://www.mdpi.com/1718-7729/30/1/6