The Complexity of the cGAS-STING Pathway in CNS Pathologies

Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate the progression of many CNS pathologies both acute and chronic. The role of adaptor protein Stimulator of Interferon Genes (STING) is increasingly appreciated to instigate type-I IFN-mediated neuroinflammatio...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Amelia L. Fryer, Amar Abdullah, Juliet M. Taylor, Peter J. Crack
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Subjects:	STING neuroinflammation interferon central nervous system cGAS
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2021.621501/full