Evaluation of Pharmacokinetic Drug–Drug Interactions: A Review of the Mechanisms, In Vitro and In Silico Approaches

Pharmacokinetic drug–drug interactions (DDIs) occur when a drug alters the absorption, transport, distribution, metabolism or excretion of a co-administered agent. The occurrence of pharmacokinetic DDIs may result in the increase or the decrease of drug concentrations, which can significantly affect...

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Bibliographic Details

Published in:	Metabolites
Main Authors:	Yaru Peng, Zeneng Cheng, Feifan Xie
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Subjects:	drug–drug interactions pharmacokinetics physiologically based pharmacokinetic model cytochrome P450 transporter
Online Access:	https://www.mdpi.com/2218-1989/11/2/75