Structure-informed clustering for population stratification in association studies

Abstract Background Identifying variants associated with complex traits is a challenging task in genetic association studies due to linkage disequilibrium (LD) between genetic variants and population stratification, unrelated to the disease risk. Existing methods of population structure correction u...

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Bibliographic Details
Published in:BMC Bioinformatics
Main Authors: Aritra Bose, Myson Burch, Agniva Chowdhury, Peristera Paschou, Petros Drineas
Format: Article
Language:English
Published: BMC 2023-10-01
Subjects:
Association studies
Populations structure
Clustering
Online Access:https://doi.org/10.1186/s12859-023-05511-w

Internet

https://doi.org/10.1186/s12859-023-05511-w

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