TLR7/TLR9- and B Cell Receptor-Signaling Crosstalk: Promotion of Potentially Dangerous B Cells

B cells are capable of receptor-mediated responses to foreign antigens. Recognition of microbial-derived nucleic acid (NA) by toll-like receptors (TLRs) 7 and 9 in B cells has been substantiated. Endogenous NA released from damaged or dying cells can also be immunogenic in certain contexts and can i...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Amy N. Suthers, Stefanie Sarantopoulos
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-07-01
Subjects:	B cell signaling TLR9 TLR7 chronic graft-versus-host disease allogeneic hematopoietic stem cell transplantation B cell receptor
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00775/full