Urea Synthesis from Isocyanides and <i>O</i>-Benzoyl Hydroxylamines Catalyzed by a Copper Salt

In the presence of CuOAc, a series of unsymmetric ureas can be generated in moderate to good yields under mild reaction conditions (10 mol% of CuOAc, 2 equiv <i>t</i>-BuONa or PhONa, 30 °C), using aryl isocyanides and <i>O</i>-benzoyl hydroxylamines as the readily accessible...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Ning Yu, Jing-Fang Lv, Shi-Mei He, Yanyan Cui, Ye Wei, Kun Jiang
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Subjects:	copper catalysis isocyanides hydroxylamines ureas insertion
Online Access:	https://www.mdpi.com/1420-3049/27/23/8219