PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes.

In T cells PKCθ mediates the activation of critical signals downstream of TCR/CD28 stimulation. We investigated the molecular mechanisms by which PKCθ regulates NFκB transactivation by examining PKCθ/β single and double knockout mice and observed a redundant involvement of PKCθ and PKCβ in this sign...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Nikolaus Thuille, Katarzyna Wachowicz, Natascha Hermann-Kleiter, Sandra Kaminski, Friedrich Fresser, Christina Lutz-Nicoladoni, Michael Leitges, Margot Thome, Ramin Massoumi, Gottfried Baier
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Online Access:	https://doi.org/10.1371/journal.pone.0053709