Mediator complex subunit 1 promotes oral squamous cell carcinoma progression by activating MMP9 transcription and suppressing CD8+ T cell antitumor immunity

Abstract Background The role of Mediator complex subunit 1 (MED1), a pivotal transcriptional coactivator implicated in diverse biological pathways, remains unexplored in the context of oral squamous cell carcinoma (OSCC). This study aims to elucidate the contributory mechanisms and potential impact...

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Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Zhe Li, Mengke Sun, Ruimeng Yang, Zheng Wang, Qianyu Zhu, Yue Zhang, Haosun Yang, Zhaosong Meng, Lizhi Hu, Lei Sui
Format:	Article
Language:	English
Published:	BMC 2024-09-01
Subjects:	The Mediator complex subunit 1 Matrix metalloprotein 9 Transcriptional regulation Programmed death-ligand 1 Notch signaling pathway Oral squamous cell carcinoma
Online Access:	https://doi.org/10.1186/s13046-024-03191-9