Dynamic transcriptome analysis measures rates of mRNA synthesis and decay in yeast

Abstract To obtain rates of mRNA synthesis and decay in yeast, we established dynamic transcriptome analysis (DTA). DTA combines non‐perturbing metabolic RNA labeling with dynamic kinetic modeling. DTA reveals that most mRNA synthesis rates are around several transcripts per cell and cell cycle, and...

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Bibliographic Details

Published in:	Molecular Systems Biology
Main Authors:	Christian Miller, Björn Schwalb, Kerstin Maier, Daniel Schulz, Sebastian Dümcke, Benedikt Zacher, Andreas Mayer, Jasmin Sydow, Lisa Marcinowski, Lars Dölken, Dietmar E Martin, Achim Tresch, Patrick Cramer
Format:	Article
Language:	English
Published:	Springer Nature 2011-01-01
Subjects:	gene expression gene regulation mRNA transcription mRNA turnover salt stress response
Online Access:	https://doi.org/10.1038/msb.2010.112