Hypoxia-Inducible Factor-1α Dependent Pathways Mediate the Renoprotective Role of Acetazolamide Against Renal Ischemia-Reperfusion Injury

Background/Aims: Acute kidney injury (AKI) is a major complication of kidney transplantation, resulting in early graft dysfunction. Since diuretic acetazolamide (AZA) has been shown to improve contrast induced AKI, we hypothesized that AZA also protected against ischemia-reperfusion (I/R) caused AKI...

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Bibliographic Details

Published in:	Cellular Physiology and Biochemistry
Main Authors:	Yu An, Jian-zhao Zhang, Jing Han, Hao-peng Yang, Lu Tie, Xiao-yuan Yang, Yilixiati Xiaokaiti, Yan Pan, Xue-jun Li
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2013-11-01
Subjects:	Acute kidney injury Kidney transplantation Ischemia reperfusion Acetazolamide Hypoxia-inducible factor-1α
Online Access:	http://www.karger.com/Article/FullText/354515