Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets

BackgroundType 2 Diabetes Mellitus (T2DM) represents a major global health challenge, marked by chronic hyperglycemia, insulin resistance, and immune system dysfunction. Immune cells, including T cells and monocytes, play a pivotal role in driving systemic inflammation in T2DM; however, the underlyi...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Huahua Li, Lingling Zou, Zhaowei Long, Junkun Zhan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Subjects:	type 2 diabetes mellitus (T2DM) single-cell RNA sequencing immunometabolism T cells machine learning models
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1537909/full