Huang-Lian-Jie-Du decoction alleviates cognitive deficits in Alzheimer’s disease model 5xFAD mice by inhibiting Trem2/Dap12 signaling pathway

Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder predominantly affecting the elderly population. It is characterized by cognitive deficits associated with the accumulation of amyloid-beta plaques and neurofibrillary tangles. Huang-Lian-Jie-Du (HLJD) decoction,...

Full description

Bibliographic Details

Published in:	Chinese Medicine
Main Authors:	Rui-Kang Pang, Jia Shi, Xiang-Yu Peng, Shan Su, Jia-Yi Zheng, Kai Le, Vincent W. Keng, Shi-Jie Zhang, Xiao-Xiao Li
Format:	Article
Language:	English
Published:	BMC 2025-04-01
Subjects:	Alzheimer’s disease Huang-Lian-Jie-Du decoction Microglia Neuroinflammation Trem2 Dap12
Online Access:	https://doi.org/10.1186/s13020-025-01098-x