IL-1β enhances cell viability and decreases 5-FU sensitivity in novel colon cancer cell lines derived from African American patients

BackgroundIn the U.S., African Americans (AAs) present with the highest incidence and mortality rates for Colorectal Cancer (CRC). When compared to Caucasian American (CA) patients, AAs also have reduced response to the first line standard of care chemotherapeutic agent 5-Fluorouracil (5-FU). Previo...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Marzia Spagnardi, Jenny Paredes, Jovanny Zabaleta, Jone Garai, Tiana Reyes, Laura A. Martello, Jennie L. Williams
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Subjects:	African American colon cancer health disparities Interleukin-1β 5-FU IL-1Ra
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.1010380/full