Enhanced HIV immune responses elicited by an apoptotic single-cycle SHIV lentivector DNA vaccine

BackgroundHIV remains a major public health issue in spite of antiretroviral therapy (ART). An innovative vaccine that can induce long-lasting and effective immunity is required to curb the persistently high numbers of new infections worldwide.MethodsA novel DNA vaccine was generated using a Simian-...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Deepanwita Bose, Kenneth A. Rogers, Lisa M. Shirreff, Yahia Chebloune, Francois J. Villinger
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Subjects:	SHIV DNA vaccine lentivector apoptotic gene immune responses mouse immunization
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2025.1481427/full