Visualization of spatiotemporal dynamics of human glioma stem cell invasion

Abstract Glioblastoma exhibits phenotypic and genetic heterogeneity, aggressive invasiveness, therapeutic resistance, and tumor recurrence, which can be explained by the existence of glioma stem cells (GSCs). In this study, we visualized the spatiotemporal dynamics of invasion of human GSCs in an or...

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Bibliographic Details

Published in:	Molecular Brain
Main Authors:	Ryota Tamura, Hiroyuki Miyoshi, Oltea Sampetrean, Munehisa Shinozaki, Yukina Morimoto, Chizuru Iwasawa, Raita Fukaya, Yutaka Mine, Hirotaka Masuda, Tetsuo Maruyama, Minoru Narita, Hideyuki Saya, Kazunari Yoshida, Hideyuki Okano, Masahiro Toda
Format:	Article
Language:	English
Published:	BMC 2019-05-01
Subjects:	Glioblastoma Glioma stem cell Invasion Brain slice culture Time-lapse imaging Tissue clearing
Online Access:	http://link.springer.com/article/10.1186/s13041-019-0462-3