Two Signaling Modes Are Better than One: Flux-Independent Signaling by Ionotropic Glutamate Receptors Is Coming of Age

Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamatergic transmission can be mediated by ionotropic glutamate receptors (iGluRs), which mediate rapid synaptic depolarization that can be associated with Ca²⁺ entry and activity-dependent ch...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Valentina Brunetti, Teresa Soda, Roberto Berra-Romani, Giovambattista De Sarro, Germano Guerra, Giorgia Scarpellino, Francesco Moccia
Format:	Article
Language:	English
Published:	MDPI AG 2024-04-01
Subjects:	glutamate ionotropic glutamate receptors AMPA receptors kainate receptors NMDA receptors flux-independent signaling
Online Access:	https://www.mdpi.com/2227-9059/12/4/880