The chondroitin sulfate moiety mediates thrombomodulin-enhanced adhesion and migration of vascular smooth muscle cells

Abstract Background Thrombomodulin (TM), a transmembrane glycoprotein highly expressed in endothelial cells (ECs), is a potent anticoagulant maintaining circulation homeostasis. Under inflammatory states, TM expression is drastically reduced in ECs while vascular smooth muscle cells (VSMCs) show a r...

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Bibliographic Details

Published in:	Journal of Biomedical Science
Main Authors:	Vincent Chunpeng Pai, I-Chung Lo, Yan wun Huang, I-Ching Tsai, Hui-Pin Cheng, Guey-Yueh Shi, Hua-Lin Wu, Meei Jyh Jiang
Format:	Article
Language:	English
Published:	BMC 2018-02-01
Subjects:	Thrombomodulin Chondroitin sulfate moiety Migration Adhesion Vascular smooth muscle cells
Online Access:	http://link.springer.com/article/10.1186/s12929-018-0415-7