Simple models to understand complex disease: 10 years of progress from Caenorhabditis elegans models of amyotrophic lateral sclerosis and frontotemporal lobar degeneration

The nematode Caenorhabditis elegans are a powerful model system to study human disease, with numerous experimental advantages including significant genetic and cellular homology to vertebrate animals, a short lifespan, and tractable behavioral, molecular biology and imaging assays. Beginning with th...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Randall J. Eck, Jade G. Stair, Brian C. Kraemer, Nicole F. Liachko
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-01-01
Subjects:	C. elegans neurodegeneration amyotrophic lateral sclerosis frontotemporal lobar degeneration TDP-43 C9orf72
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2023.1300705/full