CRISPR/Cas9-mediated editing of VHL in induced pluripotent stem cells: A model for early cell fate in von Hippel-Lindau syndrome

The von Hippel–Lindau (VHL) tumor suppressor gene is crucial for cellular homeostasis, and its loss leads to VHL syndrome. To model early effects of VHL deficiency, we used CRISPR/Cas9 to generate human iPSC lines with heterozygous or homozygous out-of-frame deletions in exon 1. Both clones showed n...

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Bibliographic Details

Published in:	Stem Cell Research
Main Authors:	Tim F. Grüner, Haribaskar Ramachandran, Anitha C. Thomas, Barbara Hildebrandt, Sven Gläsker, Jochen Dobner, Andrea Rossi
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S1873506125000984