Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways

Abstract Background The dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of the muscle cell membrane, providing a mechanical link between the extracellular matrix (ECM) and the cortical cytoskeleton that stabilizes the sarcolemma during repeated muscle contractions. One integral...

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Bibliographic Details

Published in:	Skeletal Muscle
Main Authors:	Jackie L. McCourt, Kristen M. Stearns-Reider, Hafsa Mamsa, Pranav Kannan, Mohammad Hossein Afsharinia, Cynthia Shu, Elizabeth M. Gibbs, Kara M. Shin, Yerbol Z. Kurmangaliyev, Lauren R. Schmitt, Kirk C. Hansen, Rachelle H. Crosbie
Format:	Article
Language:	English
Published:	BMC 2023-01-01
Subjects:	Duchenne muscular dystrophy Dystrophin Dystroglycan Extracellular matrix Sarcospan
Online Access:	https://doi.org/10.1186/s13395-022-00311-x