Elderly mice with history of acetaminophen intoxication display worsened cognitive impairment and persistent elevation of astrocyte and microglia burden

Abstract Acetaminophen (APAP) is a leading cause of acute liver failure. The effect of APAP metabolite’s effects in the periphery are well characterized; however, associated consequences in the brain remain poorly understood. Animal studies on this subject are few and reveal that frequent APAP intak...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Celso S. G. Catumbela, Rodrigo Morales
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-06-01
Subjects:	Acetaminophen (APAP) Acute liver failure (ALF) Elderly Cognitive decline Astrocytes Microglia
Online Access:	https://doi.org/10.1038/s41598-024-65185-z