Deficiency of heme-regulated eIF2α kinase decreases hepcidin expression and splenic iron in HFE−/− mice
Heme-regulated eIF2α kinase (HRI) is essential for regulating globin translation in iron deficiency and in β-thalassemia. We investigated the role of heme-regulated eIF2α kinase in hemoglobin and red blood cell production as well as in iron homeostasis in a mouse model of iron overload. We show that...
| Published in: | Haematologica |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Ferrata Storti Foundation
2008-05-01
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| Online Access: | https://haematologica.org/article/view/4849 |