Cell based high-throughput screening for small molecule inhibitors of ATE1

Arginyltransferase 1 (ATE1) catalyzes post-translational arginylation, a process implicated in protein stability, cellular function, and disease pathology. Dysregulated arginylation is associated with neurodegenerative disorders, cancer, and inflammation. Particularly, the increase of ATE1 activity...

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Bibliographic Details

Published in:	SLAS Discovery
Main Authors:	Claudia McCown, Evan A. Ambrose, Devang M. Patel, Hassan Al-Ali, Louis Scampavia, Fangliang Zhang, Timothy P. Spicer
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Subjects:	Arginyltransferase 1 Cell-based ATE1 uHTS Multiplex readout UF Scripps
Online Access:	http://www.sciencedirect.com/science/article/pii/S2472555225000565