Design, synthesis, and in vitro, in vivo, and in silico evaluation of novel substituted 1,3,4-thiadiazole derivatives as anticonvulsant agents

In the present study, a library of ten novel substituted 1,3,4‐thiadiazole derivatives were designed and synthesized using an appropriate synthetic route. The characterization of the synthesized compounds was performed by FT-IR and NMR (1H and 13C) spectroscopy. The synthesized compounds were assaye...

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Bibliographic Details

Published in:	Frontiers in Chemistry
Main Authors:	Tulika Anthwal, Swati Pant, Preeti Rana, Sumitra Nain
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Subjects:	1,3,4-thiadiazoles carbonic anhydrase anticonvulsant activity maximal electroshock seizure subcutaneous pentylenetetrazole
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2024.1515866/full